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#NEPTUNES BEAT TRIAL#

you have had treatment, or are currently having treatment, with abiraterone, enzalutamide, docetaxel, cabazitaxel or radium 223.you are willing to have a sample of tissue taken ( biopsy ) if there isn’t a suitable sample available that doctors can use for the immunogenic signature test.you have adenocarcinoma of the prostate (prostate cancer) that has spread to other parts of the body.

#NEPTUNES BEAT TRIAL#

You may be able to join the 1st part of this trial if all of the following apply: Talk to your doctor or the trial team if you are unsure about any of these. The following bullet points list the entry conditions for this trial. The main aim of this trial is to find out whether nivolumab and ipilimumab help men with castration resistant prostate cancer who have a positive immunogenic signature test. In the 2nd part of this trial, you have nivolumab and ipilimumab. You go to the 2nd part of this trial if doctors find certain gene changes and a difference in the amount of proteins in the cell (positive immunogenic signature) that may make you more responsive to immunotherapy treatment.

proteins on the surface of cancer cellsĭoctors call this immunogenic signature test.

First, doctors test a sample of your cancer for: Both drugs seek out cancer cells by looking for proteins on the surface of the cancer cells and blocking them so that the immune system recognises them and kills them. Nivolumab and ipilimumab are 2 types of immunotherapy. In this trial, they are looking at 2 drugs called nivolumab and ipilimumab. But doctors are looking for new ways to help men in this situation.

You usually have chemotherapy for castration resistant prostate cancer. This is called castration resistant prostate cancer. hormone therapy to reduce the level of testosterone in your bodyīut after some time, prostate cancer can start to grow again because the treatment has stopped working.

surgery to remove the testicles ( orchidectomy).So, for advanced prostate cancer you might have: Testosterone is produced by the testicles. Prostate cancer needs the male sex hormone testosterone to grow.